Link to NCBI publications:

https://www.ncbi.nlm.nih.gov/myncbi/sarah.hengel.1/bibliography/public/

Link to Google Scholar:

https://scholar.google.com/citations?user=um6EwIkAAAAJ&hl=en&oi=ao

Diversity, Equity, & Inclusion:

Woitowich, N. C., Hengel S.R., Vilgalys, T.P., Babdor, J., and Tyrell D.J. “Analysis of NIH Biomedical Faculty K99 Awards, Transitions, and R00 Outcomes. BioRXiv Preprint (: doi: https://doi.org/10.1101/2023.01.26.525751 )

Yeast Shu Complex (Csm2,Psy3,Shu1,Shu2):

Bonilla B, Brown AJ, Hengel SR, Rapchak KS, Mitchell D, Pressimone CA, Fagunloye AA, Luong TT, Russell RA, Vyas RK, Mertz TM, Zaher HS, Mosammaparast N, Malc EP, Mieczkowski PA, Roberts SA, Bernstein KA. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Elife. 2021 Nov 1;10. doi: 10.7554/eLife.68080. PubMed PMID: 34723799; PubMed Central PMCID: PMC8610418.

Rosenbaum JC, Bonilla B, Hengel SR, Mertz TM, Herken BW, Kazemier HG, Pressimone CA, Ratterman TC, MacNary E, De Magis A, Kwon Y, Godin SK, Van Houten B, Normolle DP, Sung P, Das SR, Paeschke K, Roberts SA, VanDemark AP, Bernstein KA. The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway. Nat Commun. 2019 Aug 5;10(1):3515. doi: 10.1038/s41467-019-11374-8. PubMed PMID: 31383866; PubMed Central PMCID: PMC6683157.

Bonilla B, Hengel SR, Grundy MK, Bernstein KA. RAD51 Gene Family Structure and Function. Annu Rev Genet. 2020 Nov 23;54:25-46. doi: 10.1146/annurev-genet-021920-092410. Epub 2020 Jul 14. Review. PubMed PMID: 32663049; PubMed Central PMCID: PMC7703940.

Human RAD52:

Stefanovie B, Hengel SR, Mlcouskova J, Prochazkova J, Spirek M, Nikulenkov F, Nemecek D, Koch BG, Bain FE, Yu L, Spies M, Krejci L. DSS1 interacts with and stimulates RAD52 to promote the repair of DSBs. Nucleic Acids Res. 2020 Jan 24;48(2):694-708. doi: 10.1093/nar/gkz1052. PubMed PMID: 31799622; PubMed Central PMCID: PMC6954417.

Hengel SR, Malacaria E, Folly da Silva Constantino L, Bain FE, Diaz A, Koch BG, Yu L, Wu M, Pichierri P, Spies MA, Spies M.Small-molecule inhibitors identify the RAD52-ssDNA interaction as critical for recovery from replication stress and for survival of BRCA2 deficient cells. Elife. 2016 Jul 19;5. doi: 10.7554/eLife.14740. PubMed PMID: 27434671; PubMed Central PMCID: PMC4982760.

Hengel SR, Spies MA, Spies M. Small-Molecule Inhibitors Targeting DNA Repair and DNA Repair Deficiency in Research and Cancer Therapy. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119. doi: 10.1016/j.chembiol.2017.08.027. Review. PubMed PMID: 28938088; PubMed Central PMCID: PMC5679738.

MSH2-MSH6:

Honda M, Okuno Y, Hengel SR, Martín-López JV, Cook CP, Amunugama R, Soukup RJ, Subramanyam S, Fishel R, Spies M.Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):E316-25. doi: 10.1073/pnas.1312988111. Epub 2014 Jan 6. PubMed PMID: 24395779; PubMed Central PMCID: PMC3903253.

PDZ domain:

Liu X, Speckhard DC, Shepherd TR, Sun YJ, Hengel SR, Yu L, Fowler CA, Gakhar L, Fuentes EJ. Distinct Roles for Conformational Dynamics in Protein-Ligand Interactions.Structure. 2016 Dec 6;24(12):2053-2066. doi: 10.1016/j.str.2016.08.019. Epub 2016 Oct 27. PubMed PMID: 27998539; PubMed Central PMCID: PMC5488749.

Zhang J, Sapienza PJ, Ke H, Chang A, Hengel SR, Wang H, Phillips GN, Lee AL. Crystallographic and nuclear magnetic resonance evaluation of the impact of peptide binding to the second PDZ domain of protein tyrosine phosphatase 1E.Biochemistry. 2010 Nov 2;49(43):9280-91. doi: 10.1021/bi101131f. PubMed PMID: 20839809; PubMed Central PMCID: PMC3001272.

Collaborations:

Wan L, Toland S, Robinson-McCarthy LR, Lee N, Schaich MA, Hengel SR, Li X, Bernstein KA, Van Houten B, Chang Y, Moore PS. Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity. Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2308010120. doi: 10.1073/pnas.2308010120. Epub 2023 Jul 17. PMID: 37459531.