Dr. Sarah R. Hengel

Hi! My name is Sarah and I’m an Assistant Professor at Tufts University in the Biology Department. My work is supported internally in the Tufts Biology Department by a Merrin Fund for Faculty Excellence and a R00 from the NIEHS.

My long-term goal is to mechanistically understand the intersection of DNA repair proteins involved in replication stress from divergent pathways. My research program is specifically focused on uncovering the underlying mechanisms of how DNA repair proteins from single-strand annealing (SSA), homologous recombination (HR), chromatin structural regulators, and transcription coupled repair (TCR) function together to resolve replicative stress structures that occur in our genome.

I am an expert on RAD51-dependent or RAD52-dependent repair mechanisms and our lab routinely purifies: RAD52, RAD51, DSS1, CSA, CSB, RPA, and Alt-RPA.

Our work advances fundamental knowledge of DNA mechanisms that are involved in female reproductive cancers like ovarian cancer. We are also interested in genetic variations in female reproductive diseases like endometriosis, PCOS, and POI.

My lab combines cell biology, biochemistry, biophysics, and single-molecule tweezers (C-trap) approaches to uncover novel functions of DNA repair proteins.

When I’m not in the lab I’m spending time with my partner & our three doggos, painting, and advocating to make science a more inclusive and safe place for all human beings.

PhD Graduate Students:

Steven Yu (Third Year PhD Student)

Maggie Witham (Second Year PhD Student)

Jamaurie James (Second Year PhD Student)

Undergraduate Researchers:

Shoshana Daly (Tufts Biochemistry Senior)

Lily Tiantian Gu (Tufts Biopsychology Senior)

Nicole Dacey (Tufts Biochemistry Junior)

Hannah Selverian (Tufts Biochemistry Sophomore)

Laboratory Alumni:

Oluchi C. Ezekwenna M.S. Biology at Tufts University (Now Research Associate in Dr. Agnel Sfeir Lab at Sloan Kettering)

Madeline J. Mueller B.S. Biochemistry at Tufts University (Now Research Associate in Dr. William R. Sellers Lab at The Broad Institute)