Dr. Sarah R. Hengel

Hi! My name is Sarah and I’m an Assistant Professor at Tufts University in the Biology Department. My work is supported internally in the Tufts Biology Department by a Merrin Fund for Faculty Excellence and a R00 from the NIEHS.

My long-term goal is to mechanistically understand the intersection of repair proteins involved in DNA lesion recognition and homologous recombination. My research program is specifically focused on uncovering the underlying mechanisms of how DNA damage at replication forks is recognized by the human Shu complex and repaired by either RAD51-dependent or RAD52-dependent damage repair mechanisms.

My lab combines cell biology, biochemistry, biophysics, and single-molecule tweezers (C-trap) approaches to uncover novel insights into the mechanisms of DNA repair in  aging, disease, and cancer.  

When I’m not in the lab I’m spending time with my partner & our three doggos, painting, and advocating to make science a more inclusive and safe place for all humans.

PhD Graduate Students:

Steven Yu

Maggie Witham

Jamaurie James

Undergraduate Researchers:

Shoshana Daly

Nicole Dacey

Hannah Selverian

Laboratory Alumni:

Oluchi C. Ezekwenna M.S. Biology at Tufts University

Madeline J. Mueller B.S. Biochemistry at Tufts University